ArticleCureus2025
Grade 3 Dermatitis Secondary to Two Aromatase Inhibitors in Early Hormone Receptor-Positive Breast Cancer: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Aromatase inhibitors (AIs) are widely used in the treatment of hormone receptor-positive breast cancer (HR+BC). AIs reduce the risk of HR+BC recurrence and improve disease-free survival (DFS) compared with other endocrine therapies (ETs). We report a rare case of an early, severe dermatological adverse event (dAE) to two AIs in a pre-menopausal patient receiving adjuvant treatment for human epidermal growth factor receptor 2 negative (HER2-) HR+BC. The patient developed a grade 3 eruptive, maculopapular dermatitis to exemestane and subsequently letrozole. The rash was poorly responsive to conservative management and only resolved following withdrawal of the AI. Unusually, a third AI - anastrozole - has been well tolerated. Severe dAEs secondary to AIs are rare, and there is a lack of evidence-based research to guide management of these reactions.
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