ArticleDrug design, development and therapy2025
Optimizing Venlafaxine Therapy in Pregnancy: A Maternal-Fetal PBPK Modeling Approach.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background: Pregnancy-induced physiological changes can substantially alter venlafaxine pharmacokinetics. Despite the clinical relevance of both venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), no physiologically-based pharmacokinetic (PBPK) models have been developed that simultaneously describe their disposition during pregnancy. In this study a PBPK model was developed to predict maternal and fetal exposure to venlafaxine and ODV and to optimize dosing regimens. Methods: PBPK models for venlafaxine and ODV in non-pregnant women, pregnant women, and the fetal-placental unit were developed using the Simcyp Results: In non-pregnant women, observed venlafaxine and ODV concentrations fell within the 95% confidence intervals of model predictions, with C Conclusion: A venlafaxine dose of 150 mg/day is recommended during pregnancy, balancing efficacy with the risk of toxicity in both mother and fetus.
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