ReviewDrug design, development and therapy2025
Momordicae Semen: A Review of Phytochemistry, Pharmacology, Toxicology, Herbal Processing, Clinical Applications, and Q-Markers Prediction.
Review in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Processing enhances the anti-hepatocellular carcinoma effect of Momordicae Semen via remodeling chemical composition and regulating the Akt/mTOR/STAT3 pathway.Biochemistry and biophysics reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Momordicae Semen (MS), a traditional Chinese medicine (TCM), is clinically used to disperse stagnation, reduce swelling, detoxify, and treat sores.. However, its therapeutic potential is limited by inherent toxicity and insufficient quality control standards that fail to reflect its therapeutic value. This review comprehensively synthesizes recent advances in MS research, encompassing phytochemistry, pharmacology, toxicology, herbal processing, and clinical applications. Phytochemical studies have identified a diverse range of bioactive compounds in MS, including triterpenoids and saponins, volatile oils, lignans, phenolic acids, flavonoids, steroids, proteins, peptides, and nitrogenous compounds. Pharmacological studies reveal its broad biological activities, such as antitumor, anti-inflammatory, antimicrobial, antiviral, antiulcer, antioxidant, immunomodulatory, hypolipidemic, hypotensive, and neuroprotective activities. Additionally, the applications of MS in TCM formulations and processed products are summarized, and prospects are examined. Furthermore, its potential quality markers (Q-markers) were systematically predicted based on the principles of specificity, measurability, efficacy correlation, traditional property, transfer and traceability, and network pharmacology. Despite these advances, critical challenges remain, including a limited understanding of its toxicological mechanisms, the processing-induced reduction of toxicity, the metabolic pathways of active constituents, and the need for comprehensive quality control standards. Addressing these issues through future research is essential to enhance the clinical utility and therapeutic potential of MS. This review provides a systematic reference and targeted directions for subsequent studies, which is crucial for realizing the safe, effective, and standardized application of MS in clinical practice and pharmaceutical development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.