Evidence map›Paper›PMID 41311999›Full record

ReviewThe EPMA journal2025

Repurposing holistic effects of metformin from diabetes management to skin wound healing: a 3PM-guided innovation.

Shaoyu Zhou, Kun Zhang, Bingjie Cai, Jingan Li, Guangwen Yin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The EPMA journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shaoyu ZhouDepartment of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052 P.R. China.
Kun ZhangSchool of Life Science, Zhengzhou University, Zhengzhou, Henan Province 450001 P.R. China.
Bingjie CaiDepartment of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052 P.R. China.
Jingan LiSchool of Materials Science and Engineering, Zhengzhou University, Zhengzhou, Henan Province 450001 P.R. China.
Guangwen YinDepartment of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052 P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin has recently garnered attention for its unique role in cellular metabolism regulation, prompting investigations into its potential applications in skin wound healing. Predictive, preventive, and personalized medicine (PPPM/3PM) is the most advantageous healthcare framework and is appropriate for managing chronic illnesses. This review systematically outlines the key signaling pathways through which metformin modulates inflammatory responses via metabolic reprogramming. Integrating the 3PM concept, it explores innovative application strategies for metformin in wound management, thereby proposing a working hypothesis: metformin may be utilized for personalized prevention and treatment of skin wounds. It focuses on the latest research advances in the field of wound healing, particularly the potential of metformin in local applications, as well as studies combining it with innovative carriers such as hydrogels, nanofibers, and microneedles. These studies not only expand the therapeutic scope of metformin but also provide novel perspectives and solutions to the management of chronic wounds.

Indexed as

Chronic wound managementDiabetes careHealth risk assessmentHolistic wellnessImproved individual outcomesIndividualized patient profile and rehabilitationInflammationMetabolic pathways and reprogrammingMetforminMitochondrial quality control and homeostasisPredictive diagnosticsPredictive preventive personalized medicine (PPPM / 3PM)Targeted preventionWound healing

Identifiers

PMID41311999
PMCPMC12647428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.