ReviewJACS Au2025
Phase-Separated Coacervates of Low-Molecular-Weight Compounds for Cytosolic Delivery and Disease Treatment.
Review in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase-Separation-Based Intelligent Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Decoding the tactics for coacervate pedestrian crossing the phospholipid membrane.Chemical science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liquid-liquid phase separation (LLPS)-driven coacervate droplets, formed by the self-assembly of phase-separating molecules, have emerged as a new platform for the intracellular delivery of macromolecular therapeutics such as antibodies, plasmids, and mRNA. Their appeal lies in their high loading capacity, low cytotoxicity, and high cellular uptake efficiency. Beyond traditional polymer and protein systems, recent advances have demonstrated that low-molecular-weight compounds, including peptides and small molecules, can also form functional coacervates. In this perspective, we will discuss and elucidate the possible mechanisms underlying coacervate cellular uptake and highlight their applications in macromolecular delivery and disease therapy. We also provide our perspective on future research directions and translational opportunities. By critically evaluating these aspects, we aim to bridge fundamental insights with translational potential while providing a promising strategy in disease treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.