Unified Asymmetric Synthesis of Aryltetralin Lactone Cyclolignans via Conformation-Assisted Radical C-H Cyclization.

Rong Yin, Xudong Wang, Rui Zhou, Lei Zhu, Jun Huang

Abstract read

In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rong YinSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.

Xudong WangSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.

Rui ZhouSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.

Lei ZhuCollege of Pharmacy, Third Military Medical University, Chongqing 200038, China.ORCID https://orcid.org/0000-0002-7870-8469

Jun HuangSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.ORCID https://orcid.org/0000-0003-1861-2390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aryltetralin lactones featuring vicinal stereogenic centers at their ring junctions are important scaffolds in pharmacologically relevant cyclolignans. Currently, the direct and efficient assembly of tetracyclic core scaffolds from simple acyclic precursors is challenging. Herein, we developed a conformation-assisted radical-initiated iodocarbocyclization of C-(

Indexed as

5-alkenylmalonatesaryltetralin lactone cyclolignansasymmetric total synthesiscollective synthesisradical C−H cyclization

Identifiers

PMID41311959

DOI10.1021/jacsau.5c01176

PMCPMC12648340

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.