Evidence map›Paper›PMID 41311955›Full record

ArticleJACS Au2025

Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22.

June Ereño-Orbea, Lijuan Pang, Taylor Sicard, Corwin Nycholat, Hong Cui, Dorota Borovsky, Antonio Franconetti, Jesús Jiménez-Barbero, James C Paulson, Jean-Philippe Julien

Abstract read
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In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

June Ereño-OrbeaProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.ORCID https://orcid.org/0000-0002-5076-2105
Lijuan PangDepartment of Immunology & Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Taylor SicardProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
Corwin NycholatDepartment of Immunology & Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Hong CuiProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
Dorota BorovskyDepartment of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Antonio FranconettiCIC bioGUNE, Parque Tecnológico de Bizkaia, Edif. 800, Derio-Bizkaia 48160, Spain.ORCID https://orcid.org/0000-0002-7972-8795
Jesús Jiménez-BarberoIkerbasque Basque Foundation for Science, Plaza Euskadi 5, Bilbao, Bizkaia 48009, Spain.ORCID https://orcid.org/0000-0001-5421-8513
James C PaulsonDepartment of Immunology & Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID https://orcid.org/0000-0003-4589-5322
Jean-Philippe JulienProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD22 is a sialic acid-binding immunoglobulin-like lectin (Siglec) that maintains a baseline level of B cell inhibition. Its function and restricted expression in B cells make CD22 a validated target in therapies against dysregulated B cells, which cause cancer and autoimmune diseases. High-affinity sialic acid-based ligands capable of competing with natural ligands to bind CD22 represent a promising therapeutic opportunity. Here, we describe the design and synthesis of a sialoside library constructed by chemical modifications on carbon C2 of 9-

Indexed as

B cellclick chemistrysialic acidSiglecX-ray crystallography

Identifiers

PMID41311955
PMCPMC12648315

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.