ReviewJACS Au2025
Autonomous Bioluminescence Systems: From Molecular Mechanisms to Emerging Applications.
Review in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Engineering glowing plants: recent progress and future directions for application-oriented design.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autonomous bioluminescence systemsgenetically encoded platforms that integrate luciferase enzymes with complete substrate biosynthetic pathwayshave emerged as transformative tools for real-time, noninvasive imaging in living systems. Unlike conventional substrate-dependent bioluminescence, these systems provide continuous light emission without external substrates, enabling long-term monitoring with minimal phototoxicity compared to the use of fluorescence. Here, we present a critical perspective on recent advances in the two best-characterized autonomous systems: bacterial and fungal bioluminescence systems. We assess their molecular mechanisms, protein engineering strategies, and emerging applications in single-cell imaging, multicolor biosensing, and whole-organism monitoring. By comparing their strengths and limitations, we highlight persistent challenges, such as low quantum yield in bacterial bioluminescence and substrate availability constraints in fungal bioluminescence, and discuss strategies to address themincluding AI-guided mutagenesis,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.