Evidence map›Paper›PMID 41311935›Full record

ArticleJACS Au2025

A General Approach for Strained Ring Functionalization via Nucleophilic Catalysis.

Ping Wang, Cheng Deng, Zihao Luo, Ding Chen, Alex Yida Li, Yuanqiang Li, Lin Huang, Peng Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ping WangEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang 315200, P. R. China.
Cheng DengProcess Research and Development Department, Zhejiang Jiuzhou Pharmaceutical Co. Ltd., Taizhou, Zhejiang 318000, P. R. China.
Zihao LuoProcess Research and Development Department, Zhejiang Jiuzhou Pharmaceutical Co. Ltd., Taizhou, Zhejiang 318000, P. R. China.
Ding ChenProcess Research and Development Department, Zhejiang Jiuzhou Pharmaceutical Co. Ltd., Taizhou, Zhejiang 318000, P. R. China.
Alex Yida LiDepartment of Human Biology, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Yuanqiang LiProcess Research and Development Department, Zhejiang Jiuzhou Pharmaceutical Co. Ltd., Taizhou, Zhejiang 318000, P. R. China.
Lin HuangProcess Research and Development Department, Zhejiang Jiuzhou Pharmaceutical Co. Ltd., Taizhou, Zhejiang 318000, P. R. China.
Peng YuEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang 315200, P. R. China.ORCID https://orcid.org/0000-0002-2198-5350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleophilic addition to strained rings offers an efficient route to small aliphatic rings, which serve as valuable bioisosteres in drug development. However, these reactions often require external stoichiometric bases, additives, or strong nucleophiles, limiting their practicality, compatibility, and scope. Moreover, achieving diastereocontrol in these reactions remains challenging, and direct addition of sp

Indexed as

base-freebioisoterescovalent intermediatediastereocontrolnucleophilic additionnucleophilic catalysissp3 C–H bondsstrained rings

Identifiers

PMID41311935
PMCPMC12648337

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.