Evidence map›Paper›PMID 41311934›Full record

ArticleJACS Au2025

Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy.

He Ma, Zhibin Huang, Chao Shi, Panwang Zhou, Yichen Zhou, Han Zhang, Xiao Zhou, Saran Long, Wen Sun, Jianjun Du and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Modern Cyanine Dye-Based Photosensitizers for Medical Applications.Angewandte Chemie (International ed. in English) · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

He MaState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.ORCID https://orcid.org/0000-0002-7704-7419
Zhibin HuangState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.
Chao ShiCollege of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.
Panwang ZhouState Key Laboratory of Catalysis, National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.ORCID https://orcid.org/0000-0002-9618-7038
Yichen ZhouState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.
Han ZhangState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.
Xiao ZhouState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.
Saran LongState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.
Wen SunState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.ORCID https://orcid.org/0000-0003-4316-5350
Jianjun DuState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.ORCID https://orcid.org/0000-0001-7777-079X
Jiangli FanState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.ORCID https://orcid.org/0000-0003-4962-5186
Xiaojun PengState Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China.ORCID https://orcid.org/0000-0002-8806-322X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic immunotherapy realized with photosensitizers has garnered significant interest in tumor therapy. A complete set of photosensitizer design rules has not been established yet. Herein, the side arms of thio-pentamethine cyanine dye (TCy5) are proven as crucial sites for designing efficient photosensitizers. With precise molecular design, bulky groups on the side arms can shape TCy5 as an efficient photosensitizer compared to TCy5 with alkyl groups. These bulky groups can shape the polymethine chain of TCy5 and regulate the molecular configuration, which narrows the singlet-triplet energy gap and promotes intersystem crossing. Substituting naphthyl groups for alkyl groups increased the singlet oxygen quantum yield of TCy5 from 0 to 41%. Moreover, TCy5 with naphthyl groups efficiently induced immunogenic cell death and activated immune responses in vivo, achieving effective photodynamic immunotherapy. This study serves as a paradigm that the shaping strategy via bulky groups can design efficient photosensitizers for photodynamic immunotherapy.

Indexed as

cyanineimmunogenic cell deathNIRphotodynamic immunotherapyphotodynamic therapyphotosensitizerROS

Identifiers

PMID41311934
PMCPMC12648325

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.