ArticleOpen forum infectious diseases2025
Epidemiology and Risk Factors for HCV Infection Among MSM With or at Risk of HIV in Madrid (2022-2024).
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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21 authors.
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Abstract
Background: Ongoing high-risk behaviors continue to fuel HCV transmission among men who have sex with men (MSM), challenging elimination efforts. We studied HCV epidemiology in MSM with HIV (MSM-WH) and without HIV in the region of Madrid. Methods: This prospective study (2022-2024) enrolled MSM-WH from 10 centers and MSM on PrEP from an STI clinic. Visits were scheduled at baseline, 3, 6, 9, and 12 months (PrEP group), or baseline, 6, and 12 months (HIV group). Assessments included liver enzymes, HCV serology, HCV-RNA, and STI screening (syphilis, chlamydia, and gonorrhea by PCR). Results: A total of 1372 MSM (733 with HIV; 639 on PrEP) were enrolled. Baseline HCV prevalence was 1.68%, significantly higher in those with prior HCV exposure (5.60% vs 0.72%; prevalence ratio: 7.72, 95% CI: 3.31-18.03). Over 1240.4 person-years (PY) of follow-up, overall HCV incidence was 1.45/100 PY. Primary infection incidence was 0.79/100 PY: 0.94 in PrEP users versus 0.65 in MSM-WH (IRR: 1.44, 95% CI: .24-9.80). Reinfection incidence was 4.32/100 PY overall: 12.90 in PrEP users and 4.05 in MSM-WH (IRR: 3.21, 95% CI: .07-22.53). Two participants experienced within study reinfection (8.7/100 PY, 95% CI: 1.05-31.4). Slamsex and condomless receptive anal intercourse with ≥4 partners were independently associated with HCV infection and reinfection. Conclusions: MSM with prior HCV exposure had markedly higher HCV prevalence and incidence, regardless of HIV status. Risky sexual behaviors remain key drivers of HCV transmission. Behavior-informed prevention strategies are critical to sustain elimination efforts in MSM populations.
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