Evidence map›Paper›PMID 41311904›Full record

ArticleChemical & biomedical imaging2025

A Blood-Labyrinth Barrier-Crossing Nanoprobe for Sensitive Magnetic Resonance Imaging of the Inner Ear.

Zihao Wang, Wei Ren, Xiangyu Yan, Chao Shang, Yuchao Dong, Yan Shi, Qiaohui Lu, Mingfang Huangfu, Shiyong Fan, Wu Zhong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zihao WangNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.
Wei RenNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.
Xiangyu YanState Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan 410083, P. R. China.
Chao ShangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin 130122, P. R. China.
Yuchao DongNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.
Yan ShiSenior Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Hearing and Balance Science, Chinese PLA General Hospital, Beijing 100853, P. R. China.
Qiaohui LuSenior Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Hearing and Balance Science, Chinese PLA General Hospital, Beijing 100853, P. R. China.
Mingfang HuangfuSenior Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Hearing and Balance Science, Chinese PLA General Hospital, Beijing 100853, P. R. China.
Shiyong FanNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.ORCID https://orcid.org/0000-0003-4216-8226
Wu ZhongNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.ORCID https://orcid.org/0000-0002-0536-620X
Shiming YangSenior Department of Otolaryngology Head and Neck Surgery, State Key Laboratory of Hearing and Balance Science, Chinese PLA General Hospital, Beijing 100853, P. R. China.
Xinchen LiuJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P. R. China.
Huan WangState Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.ORCID https://orcid.org/0000-0001-9464-2474

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-enhanced inner ear magnetic resonance imaging (MRI) provides clinicians with powerful structural and pathological information for the diagnosis of inner ear diseases. However, currently used gadolinium (Gd) chelate-mediated contrast-enhanced MRI conveys insufficient inner ear specificity, and Gd-based contrast agents have a short body retention time and cause severe ototoxicity. Herein, we present the rational design of a sensitive inner ear-specific nanoprobe (I-PUSPIO) for inner ear MRI that is composed of an ultrasmall iron oxide core, the IETP2 peptide, and polyethylene glycol. Such a well-defined nanostructure endows it with blood-labyrinth barrier crossing capacity, leading to a high accumulation rate in the inner ear and prolonged body retention. In vivo I-PUSPIO can enhance high-resolution MRI of cochlear tissue and shows no evidence of toxicity. This study demonstrates the potential of I-PUSPIO as a sensitive contrast agent for inner ear MRI in clinical settings.

Indexed as

high-resolution imaginginner ear imaginglong body retentionmagnetic resonance imagingnanoprobes

Identifiers

PMID41311904
PMCPMC12648414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.