Evidence map›Paper›PMID 41311898›Full record

ArticleChemical & biomedical imaging2025

Phenothiazine-Based Fluorescence-Quenched Photoacoustic Contrast Agents for Molecular Imaging.

Xuexue Huang, Yi Wang, Zhiting Wu, Mingjie Jia, Qingqing Wang, Shaojie Yuan, Hanzhi Lu, Fulun Li, Peng Wei, Tao Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuexue HuangState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Yi WangDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Zhiting WuState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Mingjie JiaState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Qingqing WangState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Shaojie YuanDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Hanzhi LuDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Fulun LiDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Peng WeiState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.ORCID https://orcid.org/0000-0003-1107-6732
Tao YiState Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.ORCID https://orcid.org/0000-0002-3309-8556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoacoustic imaging (PAI), renowned for its high spatial resolution and deep tissue penetration, holds great promise for disease diagnosis and molecular detection. However, the performance of commercially available PAI contrast agent is often hindered by intrinsic fluorescence, which reduces photoacoustic (PA) signal intensity and contrast, thereby limiting their applications. Herein, we rationally designed and synthesized a class of PAI contrast agents based on a phenothiazine core. By precise molecular engineering, we introduced a twisted intramolecular charge transfer (TICT) effect to suppress fluorescence, minimize radiative decay, and facilitate nonradiative energy dissipation, thereby enhancing photothermal conversion efficiency and significantly improving PA signal intensity and imaging contrast-to-noise ratio both

Indexed as

hypochlorous acidphenothiazinephotoacoustic contrast agentsPhotoacoustic imagingtwisted intramolecular charge transfer

Identifiers

PMID41311898
PMCPMC12648425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.