ArticlebioRxiv : the preprint server for biology2025
Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
The ability to control transgene expression both temporally and quantitatively in human-relevant cells and tissues is a cornerstone of biomedical research. Additionally, precise transgene control is crucial for optimizing human cell-based gene therapies. Human pluripotent stem cells (hPSCs) have facilitated major advances in disease modeling and the potential for regenerative medicine. Still, they are significantly limited by the lack of inducible transgenic systems that avoid silencing but maintain robust inducibility after differentiation to defined cell lineages. Here we systematically characterize the leakiness, inducibility, and tunability of multiple existing and novel transgenic systems in hPSCs and differentiated macrophages and microglia. Notably, we report the application of a small molecule-mediated splicing switch (X
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