Evidence map›Paper›PMID 41311862›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart.

Reo Matsumura, Mototsugu Nishii, Haruya Usuku, Masahiro Nakayama, Masaki Hachisuka, Naho Misawa, Ryo Saji, Fumihiro Ogawa, Alan Valaperti, Yoshihiro Ishikawa and 1 more

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reo MatsumuraDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Mototsugu NishiiDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Haruya UsukuDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masahiro NakayamaDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaki HachisukaDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Naho MisawaDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ryo SajiDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Fumihiro OgawaDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Alan ValapertiDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Yoshihiro IshikawaCardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ichiro TakeuchiDepartment of Emergency Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulatory mechanisms for inflammatory response in the heart to endotoxin, which causes severe cardiac dysfunction, are not fully understood. We hypothesized the involvement of coxsackie and adenovirus receptor (CXADR), which can promote tissue inflammation by potentiating cell-cell adhesion, independent of viral infection, and examined the role of CXADR in endotoxin-induced cardiac dysfunction and its mechanism using an experimental mouse model. Conditional whole-body and endothelium-specific CXADR knockout (W-KO and

Indexed as

Cardiac dysfunctionCoxsackie and adenovirus receptorEndotoxinInflammatory cytokinep38 MAPK

Identifiers

PMID41311862
PMCPMC12651843

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.