ArticleFrontiers in pharmacology2025
Tigecycline pharmacodynamics in the hollow fiber system of
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic and quantitative analyses of hollow fiber model ofMicrobiology spectrum · 2026Pooled it
- Novel regimens for treatment ofbioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
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3 authors.
Funding
Abstract
Background: Guideline-based therapy (GBT) drugs for Methods: First, we co-incubated tigecycline with MAC for 7 days in time-kill studies and calculated the exposure mediating 50% of maximal effect (E Results: In time-kill studies, the EC Conclusion: Instead of static time-kill studies with a reference strain, inclusion of multiple MAC isolates in HFS-MAC studies improves the precision of pharmacokinetic/pharmacodynamic parameter estimates. Tigecycline administered via the inhalational route could contribute to the treatment of MAC-LD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.