ReviewOncology letters2026
Research progress on neutrophil extracellular traps and hepatitis-to-hepatocellular carcinoma transformation (Review).
Review in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Doxorubicin-induced hepatotoxicity: a multifaceted pathogenesis from mitochondrial collapse to immune remodeling and epigenetic memory.Archives of toxicology · 2026Review
- Neutrophil Elastase-Responsive Linkers for Precision Antibody-Drug Conjugates.ACS medicinal chemistry letters · 2026Article
- Review
- The role and therapeutic prospects of intercellular communication and RNA mFrontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil extracellular traps (NETs) are web-like structures released by activated neutrophils, composed of DNA, histones and antimicrobial proteins. Although initially discovered for their role in innate immunity, NETs are also closely associated with the pathogenesis of chronic hepatitis and hepatocellular carcinoma (HCC). The present review, which analyzes the latest research from databases such as PubMed and Web of Science, focuses on the formation of NETs, their roles in hepatitis (including hepatitis B, non-alcoholic steatohepatitis and ischemia-reperfusion injury) and their contributions to the initiation, progression and metastasis of HCC. The present review aimed to systematically elucidate the role of NETs in the transition from hepatitis to HCC, with a focus on underlying molecular mechanisms and potential therapeutic implications. The current findings suggest that targeting NET formation or function through inhibition of peptidylarginine deiminase 4, neutrophil elastase, DNase I or related signaling pathways may represent a promising therapeutic strategy to suppress inflammation-driven hepatocarcinogenesis and improve outcomes for patients with HCC. However, further validation is required to translate these findings into clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.