ArticleCHEST pulmonary2025
Limited Ventilatory Reserve During Exercise in Heart Failure with Preserved Ejection Fraction: Impact of Lung Size and Adiposity.
Article in CHEST pulmonary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Impact of inspiratory muscle training on inspiratory muscle metaboreflex in patients with heart failure with preserved ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Sotatercept Improves Small Airway Disease and Hyperinflation in Patients with Pulmonary Hypertension.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundPatients with heart failure with preserved ejection fraction (HFpEF) exhibit a tachypneic breathing strategy during exercise. Patients with HFpEF have pulmonary system alterations that may contribute to the breathing strategy in HFpEF. RESEARCH QUESTION: Do patients with HFpEF have limited ventilatory reserve compared with control patients during exercise? Furthermore, does greater upper body adiposity contribute to the lower ventilatory reserves in HFpEF? STUDY DESIGN AND
methodsPatients with HFpEF (n = 16; mean age ± SD, 70 ± 8 years) and control patients (n = 19; mean age ± SD, 69 ± 8 years) performed incremental cycling to volitional exhaustion. Trunk percent fat was quantified with dual-energy X-ray absorptiometry. Inspiratory capacity, inspiratory and expiratory reserve volumes, and ventilatory variables were compared between groups at rest and during exercise at 40 W and peak oxygen uptake.
resultsPatients with HFpEF had lower total lung capacity (5.4 ± 1.1 vs 6.4 ± 1.2 L), FVC (3.1 ± 0.7 vs 3.8 ± 0.6 L), and FEV
interpretationThese findings demonstrate that patients with HFpEF have limited ventilatory reserve during exercise, in part due to their smaller lung capacity. Furthermore, our findings suggest that the greater distribution of upper body adiposity in HFpEF is an important contributor to the smaller lung capacity for these patients.
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