Evidence map›Paper›PMID 41311752›Full record

ReviewCureus2025

Comparative Efficacy of Ublitixumab Versus Natalizumab in the Treatment of Relapsing and Remitting Multiple Sclerosis.

Sai V Chitturi, Jonnalagadda Amith Priyansu, Akhil Sadhu, Hemanthi Ramisetty, Manoj R Pallapothu, Deepiikha Kogantii

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sai V ChitturiFamily Medicine, Pontiac General Hospital, Pontiac, USA.
Jonnalagadda Amith PriyansuMedicine, Guntur Medical College, Guntur, IND.
Akhil SadhuFamily Medicine, Faculty of Medicine, St. Martinus University, Willemstad, CUW.
Hemanthi RamisettyNeurology, Bridgetown International University School of Medicine, Bridgetown, BRB.
Manoj R PallapothuResearch, Faculty of Medicine, St. Martinus University, Willemstad, CUW.
Deepiikha KogantiiFamily Medicine, Apollo Institute of Medical Sciences and Research, Chittoor, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapsing-remitting multiple sclerosis (RRMS) is a chronic autoimmune disorder characterized by immune-mediated demyelination and neurodegeneration, leading to progressive neurological impairment. Disease-modifying therapies (DMTs) play a crucial role in managing RRMS by reducing relapse frequency and slowing disability progression. Among these, monoclonal antibodies such as ublituximab and natalizumab have emerged as key therapeutic options with distinct mechanisms of action and safety profiles. This narrative review aims to compare the efficacy, safety, and clinical impact of ublituximab and natalizumab in the treatment of RRMS, providing insights into their role in individualized treatment strategies.

Indexed as

monoclonal antibodies (mabs)natalizumabrelapsing and remittings: multiple sclerosisublitixumab

Identifiers

PMID41311752
PMCPMC12648440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.