ReviewCureus2025
Impact of Regional Versus General Anaesthesia on Outcomes Following Total Knee Replacement: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of anesthesia in TKA length of stay: a data-driven analysis using Boruta algorithm.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total knee replacement (TKR) is widely performed for advanced osteoarthritis, and the choice between regional anaesthesia (RA) and general anaesthesia (GA) may influence perioperative outcomes. This systematic review and meta-analysis aimed to compare the impact of RA versus GA on outcomes following TKR. A comprehensive search of PubMed, Embase, Scopus, Web of Science, and the Cochrane Library was conducted for comparative studies published between January 2010 and May 2025. Nine retrospective cohort studies encompassing 522,080 TKR procedures were included. RA was associated with significantly lower odds of blood transfusion (odds ratio (OR): 0.58; 95% confidence interval (CI): 0.44-0.77; p<0.001), fewer 30-day postoperative complications (OR: 0.59; 95% CI: 0.39-0.88; p=0.01), and a shorter hospital stay (standardised mean difference (SMD): -0.09; 95% CI: -0.14 to -0.04; p<0.001). Despite moderate-to-high heterogeneity, the direction of effect consistently favoured RA. These findings suggest that RA provides superior short-term outcomes compared with GA in TKR, supporting its preferential use, particularly in high-risk or elderly patients, while reinforcing the importance of individualised anaesthetic planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.