ArticleMayo Clinic proceedings. Innovations, quality & outcomes2025
Infective Endocarditis Risk After Invasive Dental Procedures.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- An important change in infective endocarditis prevention guidance.British dental journal · 2026Article
- Observational Study on the Management of Children with Systemic Diseases During Dental Treatment.Children (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To quantify the risk of infective endocarditis (IE) following different invasive dental procedures in patients with cardiac risk factors that place them at low-risk, moderate-risk, or high-risk of developing IE. Patients and Methods: The linked IBM MarketScan administrative databases were used to integrate deidentified patient-level health data for all enrollees over 18 years of age with employer-provided commercial/Medicare-supplemental medical and dental coverage, or Medicaid benefits, with more than 16 months of data from May 1, 2007, to August 31, 2015. Results: In the resulting 9.6 million patient cohort, IE incidence in the 4-months following 53.6 million invasive dental procedures was quantified. In high-risk individuals (e.g. previous IE, prosthetic/repaired heart valves, or cyanotic congenital heart disease), IE incidence in the 4 months following an IDP was 2195 IE cases/million procedures - ∼125 times higher than in low-risk (OR 126.3; 95% CI, 113.5-140.6; Conclusion: The risk of IE was high in high-risk individuals following all types of IDP (particularly following extractions and other oral surgical procedures) and vastly exceeded the risk of adverse drug reactions following antibiotic prophylaxis. Our data therefore support guidance recommending high-risk individuals receive antibiotic prophylaxis and provide quantitative information concerning the IE-risk that can be used to educate and obtain informed consent from patients.
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Registered trials
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