Evidence map›Paper›PMID 41311639›Full record

ArticleTetrahedron letters2025

A diastereoselective preparation of cyclic α-aminoboronates.

John Kim, Anna Page, Ryan T Vanderlinden, Ryan E Looper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John KimDepartment of Chemistry, University of Utah, Rm 2020, Salt Lake City UT 84112.
Anna PageDepartment of Chemistry, University of Utah, Rm 2020, Salt Lake City UT 84112.
Ryan T VanderlindenDepartment of Chemistry, University of Utah, Rm 2020, Salt Lake City UT 84112.
Ryan E LooperDepartment of Chemistry, University of Utah, Rm 2020, Salt Lake City UT 84112.

Funding

Pd-Catalyzed Olefin Functionalization Reactions for Organic SynthesisR01GM063540 · NIGMS · UNIVERSITY OF UTAH · PI SIGMAN, MATTHEW S · 2002 to 2019
$5.3M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR017539 · NCRR · UNIVERSITY OF UTAH · PI PUGMIRE, RONALD J · 2003 to 2003
$3.8M
Development of Selective Ribosomal P-site InhibitorsR01AI127724 · NIAID · UNIVERSITY OF UTAH · PI LOOPER, RYAN EDWARD · 2017 to 2020
$1.5M
A 500MHz NMR Spectrometer with AutomationS10OD025241 · OD · UNIVERSITY OF UTAH · PI FLYNN, PETER F · 2018 to 2018
$600k
X-ray Diffraction SystemS10OD030326 · OD · UNIVERSITY OF UTAH · PI HILL, CHRISTOPHER P. · 2021 to 2021
$597k
NCRR NIH HHS C06 RR017539NIAID NIH HHS R01 AI127724NIGMS NIH HHS R01 GM063540NIH HHS S10 OD025241NIH HHS S10 OD030326
6 · The paper itself

Abstract

Chiral α-amino- and α-amidoboronates are established pharmacophores in numerous drugs and drug candidates, however, methods to prepare this motif are limited. We report the preparation of cyclic α-amino boronates via a three-component coupling reaction of salicylaldehydes, tetrahydroxydiboron, and chiral amines. Deploying 1,2-aminoalcohol and aminoacid derivatives delivers a structurally diverse set of cyclic α-aminoboronates. Moderate to high diastereoselectivity is noted both at the newly forged carbon-boron bond and at the tetrahedral boron center.

Identifiers

PMID41311639
PMCPMC12657034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.