Evidence map›Paper›PMID 41311560›Full record

ArticleAging and health research2025

Associations between Traditional Chinese Medicine Body Constitution and Cardiovascular Disease Risk in a White population.

Lihua Shu, Xiaolin Yin, Xiangzhu Zhu, Jing Zhao, Xinqing Deng, Yevheniy Eugene Shubin, Harvey J Murff, Reid M Ness, Chang Yu, Martha J Shrubsole and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lihua ShuSchool of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Xiaolin YinShanghai Municipal Hospital of Traditional Chinese Medicine affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiangzhu ZhuDepartment of Medicine, Division of Epidemiology, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Jing ZhaoAtrium Health, Center for Outcome Research and Evaluation, Charlotte, NC, USA.
Xinqing DengDepartment of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Yevheniy Eugene ShubinSaint Joseph Health System, South Bend, IN, USA.
Harvey J MurffDepartment of Medicine, Division of Geriatric Medicine; Vanderbilt University Medical Center, Nashville, TN, USA.
Reid M NessDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
Chang YuDepartment of Population Health, NYU Grossman School of Medicine, New York, New York, USA.
Martha J ShrubsoleShanghai Municipal Hospital of Traditional Chinese Medicine affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qi DaiShanghai Municipal Hospital of Traditional Chinese Medicine affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Calcium: magnesium balance, microbiota, and necroptosis and inflammationR01DK110166 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAI, QI, SHRUBSOLE, MARTHA J. · 2017 to 2021
$3.4M
Personalized Prevention of Colorectal CancerR01CA149633 · NCI · VANDERBILT UNIVERSITY · PI DAI, QI, YU, CHANG · 2010 to 2014
$2.0M
NCATS NIH HHS UL1 TR000445NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA149633NCRR NIH HHS UL1 RR024975NIDDK NIH HHS R01 DK110166
6 · The paper itself

Abstract

Background: Traditional Chinese medicine (TCM) has guided generations of practice on disease treatment and health maintenance. The TCM principles include the framework of body constitution. However, no study has assessed the body constitution in US population. Methods: This is an ancillary study of the Personalized Prevention of Colorectal Cancer Trial which conducted in US in 2012-2016. 191 white participants were evaluated for body constitution type using a self-administered Traditional Chinese Medicine Questionnaire (English version). The body constitution subtypes and cardiovascular disease (CVD) risk were assessed. Results: Fifty-seven (29.8%) were identified as balanced constitution (BC), while Blood-stasis (17.3%), Qi-deficient (13.6%), and inherited-special constitutions (10.5%) were the pre-eminent pathologic subtypes. Additional analyses investigated the relationship between CVD risk and body constitution subtypes. No major types of TCM body constitution were associated with the GCRS and other CVD biomarkers. Conclusions: It is important to understand the underlying mechanisms contributing to these differences, which may not only help to understand the underlying mechanism for TCM, but also help to identify novel factors or mechanisms for CVD risk, prevention and treatment.

Indexed as

Body ConstitutionCardiovascularChinese Traditional MedicineCRPUric acid

Identifiers

PMID41311560
PMCPMC12657019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.