ArticleMediators of inflammation2025
Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Combined Omeprazole andInternational journal of molecular sciences · 2026Article
- Research Advances on the Molecular Structural Basis and Mechanisms of Quercetin and Its Derivatives in Improving Insulin Resistance.Drug design, development and therapy · 2026Review
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9 authors.
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Abstract
Background: Aging is a multifaceted physiological process characterized by progressive multiorgan dysfunction, oxidative stress, neuronal injury, cognitive impairment, and alterations in gut microbiota composition. Licorice, a widely used traditional medicinal herb, contains diverse bioactive constituents; however, its overall antiaging properties and mechanistic basis in aging models have not been systematically elucidated. Methods: Aging mice model was established using D-galactose (D-Gal). Body weight, organ indices, senescence markers, antioxidant activity, neuronal integrity, and behavioral performance were assessed to evaluate the protective role of licorice water (LW) extract. Further, gut microbiota profiling, network pharmacology, and western blotting were employed to investigate further the potential mechanisms underlying the antiaging effects of LW. Results: LW administration significantly improved body weight gain, organ indices, and hippocampal structure in aging mice, increased antioxidant enzyme activity, and decreased the proportion of SA-β-Gal-positive cells. Moreover, LW treatment reshaped gut microbiota composition by lowering the Conclusion: These findings demonstrate that LW exerts protective antiaging effects in D-Gal-induced mice by enhancing antioxidant activities, safeguarding neuronal function to improve cognition, restoring gut microbiota balance, and modulating the PI3K/AKT/mTOR pathway, supporting its promise as a candidate for antiaging interventions.
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