ArticleFrontiers in microbiology2025
Sishen Pill treats spleen-kidney yang deficiency IBS-D by influencing ATPase activity and intestinal microbiota.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
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Abstract
Background: Sishen Pill (SSP) has therapeutic effects on spleen-kidney yang deficiency diarrhea-predominant irritable bowel syndrome (IBS-D). Studies have shown that IBS-D with spleen-kidney yang deficiency is characterized by intestinal microbiota dysbiosis and impaired ATPase activity. After SSP treatment, the abundance of beneficial microbiota increased, the balance of the intestinal microbiota was restored, and ATPase activity improved, suggesting that SSP may exert its therapeutic effects by modulating the intestinal microbiota and restoring ATPase activity. Methods: Forty SPF-grade female mice were randomly allocated into four groups (n = 10 per group): normal group (CC), spontaneous recovery group (MC), pinaverium bromide treatment group (PBT), and SSP treatment group (SSP). The IBS-D mouse model was successfully established by adenine and Results: (1) Compared with CC group, SSP group presented significantly increased Na Conclusion: SSP significantly alleviates symptoms of spleen-kidney yang deficiency in IBS-D by regulating intestinal microbiota, increasing Na
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