Evidence map›Paper›PMID 41311476›Full record

ArticleMolecular therapy. Methods & clinical development2025

Intrathalamic delivery of adeno-associated viral vector expressing progranulin as gene therapy for GRN-related frontotemporal dementia.

Youn Bok Lee, Do Young Lee, Zoe Walker, Joseph Allison, Aleksandra Kaliszewska, Alinda Fernandes, Katharine Y Zhang, Yalem Bekele, Paniz Hosseini, Romain Joubert and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TheBrain and neuroscience advances
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Youn Bok LeeAviadoBio, London E14 5GX, UK.
Do Young LeeAviadoBio, London E14 5GX, UK.
Zoe WalkerAviadoBio, London E14 5GX, UK.
Joseph AllisonUK Dementia Research Institute, King's College London, London SE5 9RT, UK.
Aleksandra KaliszewskaUK Dementia Research Institute, King's College London, London SE5 9RT, UK.
Alinda FernandesAviadoBio, London E14 5GX, UK.
Katharine Y ZhangUK Dementia Research Institute, King's College London, London SE5 9RT, UK.
Yalem BekeleAviadoBio, London E14 5GX, UK.
Paniz HosseiniAviadoBio, London E14 5GX, UK.
Romain JoubertAviadoBio, London E14 5GX, UK.
Joana FurtadoAviadoBio, London E14 5GX, UK.
McQuinn GumusUK Dementia Research Institute, King's College London, London SE5 9RT, UK.
Olivier BrockUK Dementia Research Institute, King's College London, London SE5 9RT, UK.
Ali BienemannTranslation Health Studies (THS), University of Bristol, Bristol BS8 1QU, UK.
Steven GillNeurochase, Bristol BS1 5QT, UK.
Samantha MurrayLincoln University, Lincoln 7647, New Zealand.
Nadia MitchellLincoln University, Lincoln 7647, New Zealand.
Page BouchardRising Tide Advisors, LLC, Andover, MA 01810, USA.
Alex BloomAviadoBio, London E14 5GX, UK.
John IsaacAviadoBio, London E14 5GX, UK.
Carlos J MirandaAviadoBio, London E14 5GX, UK.
Christopher E ShawAviadoBio, London E14 5GX, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adeno-associated viral vectoranimal studyAVB-101cortical biodistributionfrontotemporal dementiagene therapyintrathalamic deliverypreclinicalprogranulinthalamus

Identifiers

PMID41311476
PMCPMC12651635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.