Evidence map›Paper›PMID 41311374›Full record

ArticleBiochemistry and biophysics reports2025

Epstein-Barr virus LMP1 promotes tumorigenesis in a murine epithelial tumor model.

Jing Tan, Yalin Li, Luting Hu, Yuxiang Zhao, Weicheng Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing TanZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Yalin LiZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Luting HuZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Yuxiang ZhaoZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Weicheng YiZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV), an oncogenic herpesvirus, is associated with diverse epithelial and lymphatic malignancies. The latent membrane protein 1 (LMP1) is well-established as a key oncogenic driver in B-cell malignancies, while its functional role in epithelial tumors remains poorly understood. This study aimed to establish an epithelial tumor model stably expressing LMP1 and investigate its oncogenic functions and mechanisms. We generated mouse lung epithelial cells TC-1 stably expressing EBV LMP1 using the PiggyBac transposon system (TC-1-LMP1). The TC-1-LMP1 model demonstrated that LMP1 enhanced proliferative and invasive capacities while reducing cell adhesion in

Indexed as

Epstein-Barr virusLatent membrane protein 1Murine epithelial tumor modelMycOncogenicity

Identifiers

PMID41311374
PMCPMC12650785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.