ArticleBiochemistry and biophysics reports2025
HECTD1-mediated SFTPB overexpression in fibrotic lung induced by silica.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alveolar epithelial cells type 2 are lung progenitor and secretory cells capable of secreting four surfactant proteins, namely surfactant protein A (SFTPA), surfactant protein B (SFTPB), surfactant protein C (SFTPC), and surfactant protein D (SFTPD). Among these proteins, SFTPB not only participates in the composition of surfactant proteins but also has important immune functions. In occupational dust exposure, dust entering the bronchi and alveoli can come into direct contact and stimulate AT2. To investigate the expression of SFTPB in fibrotic lungs, we constructed a mouse pulmonary fibrosis model using silica and detected the spatial expression of SFTPB protein and SFTPB mRNA in lung sections. Herein, we observed an increase in SFTPB production from AT2 in SiO
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