Evidence map›Paper›PMID 41311339›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Magnetically Retrievable Platinum Nanoreporters for Efficient Lateral Flow Immunoassay in Complex Bio-Samples.

Yuxi Cheng, Luca Panariello, Adam Creamer, Christy J Sadler, André Shamsabadi, Kathleen Lupien, Ali Vaughan, Thomas Gervais, Molly M Stevens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxi ChengDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0003-3737-3110
Luca PanarielloDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0002-6834-5115
Adam CreamerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0002-6203-8456
Christy J SadlerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0009-0006-2763-7097
André ShamsabadiDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0001-8466-5621
Kathleen LupienDepartment of Engineering Physics, Polytechnique Montréal, Montréal, H3T 1J4, Canada.
Ali VaughanNuffield Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Thomas GervaisDepartment of Engineering Physics, Polytechnique Montréal, Montréal, H3T 1J4, Canada.ORCID 0000-0002-2025-9082
Molly M StevensDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0002-7335-266X

Funding

Cancer Research UK 100017Cancer Research UK 100063Department of Science, Innovation and TechnologyEngineering and Physical Sciences Research Council EP/K031953/1Engineering and Physical Sciences Research Council EP/R00529X/1HORIZON EUROPE Marie Sklodowska-Curie Actions 101106805Imperial College LondonMitacsNIHR Oxford Biomedical Research CentreNSERC RGPIN-2020-06838Rosetrees TrustRoyal Academy of Engineering CiET2021∖94University of Oxford Medical Sciences DivisionWellcome TrustWellcome Trust 222836/Z/21/Z
6 · The paper itself

Abstract

Lateral flow immunoassays (LFIAs) are widely used for point-of-care diagnostics, but their development is challenged by the complexity and variability of patient samples. In particular, LFIAs often exhibit reduced sensitivity and specificity when used with patient samples, compared to their performance with analyte-spiked idealized matrices. Patient samples are inherently complex, with variations in physical and biochemical properties between patients. This complexity has consequences for the performance of LFIAs, and can result in non-specific binding on the test line, discoloration of the nitrocellulose membrane, and incomplete sample flow along the test strip. To address these challenges, a magnetically retrievable platinum nanoreporter (termed Pt@Fe

Indexed as

PlatinumHumansImmunoassayPlatinumlateral flow immunoassaymagnetic separationmatrix effectplatinum nano‐catalysts

Identifiers

PMID41311339
PMCPMC12781628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.