Evidence map›Paper›PMID 41311215›Full record

ArticleActa biochimica et biophysica Sinica2025

SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells.

Jingyuan Chen, Youbo Yang, Gang Liu, Lihua Huang, Yunfei Zhang, Yufeng Wang, Xiuwen Xu, Xiaowei Xing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingyuan ChenCenter for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Youbo YangDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Gang LiuThe Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, 410078, China.
Lihua HuangCenter for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yunfei ZhangCenter for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yufeng WangDepartment of Clinical Laboratory, Sanya Central Hospital (Hainan Third People's Hospital), Sanya 572000, China.
Xiuwen XuCenter for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Xiaowei XingCenter for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolysis provides the main energy source for the rapid proliferation and migration of colorectal cancer (CRC) cells. In our previous studies, we reported that SUN5, a nuclear membrane protein, promotes proliferation and migration. However, whether SUN5 is involved in the process of glycolysis is unclear. Here, we demonstrate that overexpression of SUN5 enhances glucose uptake and lactate production in CRC cells, whereas the opposite results are observed in

Indexed as

glycolysisIκBSUN5TRIM28ubiquitination

Identifiers

PMID41311215
PMCPMC12954519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.