Evidence map›Paper›PMID 41311080›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Elevated TMCO1 expression in gastric cancer is associated poor prognosis and promotes malignant phenotypes of tumor cells by inhibiting apoptosis].

Bowen Song, Renjie Zhou, Ying Xu, Jinran Shi, Zhizhi Zhang, Jing Li, Zhijun Geng, Xue Song, Lian Wang, Yueyue Wang and 1 more

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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Bowen SongDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233030, China.
Renjie ZhouDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233030, China.
Ying XuAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Jinran ShiAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Zhizhi ZhangAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Jing LiAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Zhijun GengAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Xue SongAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Lian WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233030, China.
Yueyue WangAnhui Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Lugen ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233030, China.

Funding

National Natural Science Foundation of China 82370534
6 · The paper itself

Abstract

objectivesTo investigate the impact of high expression of transmembrane and coiled helix structural domain 1 (TMCO1) on prognosis of gastric cancer and the possible mechanisms.

methodsTMCO1 expression in gastric cancer and its effect on gastric cancer progression and prognosis were analyzed using publicly available databases and clinical data of patients undergoing radical surgery in our hospital, and its possible biological functions were explored using KEGG and GO analyses. In gastric cancer HGC-27 cells, the effects of lentivirus-mediated TMCO1 overexpression and TMCO1 silencing on cell apoptosis, proliferation, invasion and migration were examined.

resultsTMCO1 expression was significantly elevated in gastric cancer tissues (

conclusionsTMCO1 is overexpressed in gastric cancer tissues, and its high expression promotes gastric cancer progression and affects long-term prognosis of the patients possibly by activating the Wnt/ β-catenin signaling pathway to inhibit apoptosis of gastric cancer cells.

Indexed as

ApoptosisStomach Neoplasmsbeta CateninCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansPrognosisWnt Signaling Pathwaybeta Cateninapoptosisgastric cancerprognosistransmembrane and coiled-coil domain 1Wnt/β-catenin

Identifiers

PMID41311080
PMCPMC12676691

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