Evidence map›Paper›PMID 41311073›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[circ_EPHB4 synergizes with YTHDF3 to promote glioma progression

Chen Jin, Jingping Liu, Bo Liu, Xiyun Fei, Yuxiang Liao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chen JinDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Jingping LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Bo LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiyun FeiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Yuxiang LiaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the oncogenic role of circular RNA circ_EPHB4 in glioma and its molecular mechanism.

methodsMicroarray analysis was performed to identify the differentially expressed circRNAs in glioma tissues. The effects of circ_EPHB4 on glioma cell migration, invasion and epithelial-mesenchymal transition (EMT)

resultsCirc_EPHB4 was significantly overexpressed by 2.3 folds (|log2FC|=1.2,

conclusionsCirc_EPHB4 and YTHDF3 promote glioma progression by jointly targeting the Wnt3 signaling pathway, which may provide a new therapeutic strategy for gliomas.

Indexed as

Brain NeoplasmsGliomaRNA-Binding ProteinsWnt3 ProteinAdenosineAnimalsCell Line, TumorCell MovementDisease ProgressionEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMiceMice, NudeRNA, CircularAdenosineN-methyladenosineRNA-Binding ProteinsRNA, CircularWnt3 ProteinWNT3 protein, humancirc_EPHB4gliomam 6 AWnt3YTHDF3

Identifiers

PMID41311073
PMCPMC12676697

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.