ArticleBiophysical journal2026
Cold atmospheric plasma promotes migration persistence, through induced H
Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- Hydrogen Peroxide-Mediated Inhibition of Membrane Resealing Drives Synergistic Cytotoxicity of Combined Cold Atmospheric Plasma and Pulsed Electric Field Treatment.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold atmospheric plasma (CAP) generates various products, including radiation, electrons, ions, an electric field, and reactive oxygen and nitrogen species. CAP promotes wound healing and has been implemented in several medical devices to treat acute or chronic wounds. Beyond the closure of the epidermal monolayer of keratinocytes, wound healing requires migration of dermal fibroblasts. The effect of CAP on fibroblast migration has been insufficiently characterized. Here, we show, using primary human dermal fibroblasts, that a 10-s exposure to CAP suffices to increase Arp2/3-dependent lamellipodium formation and migration persistence for several hours. In an attempt to identify the specific CAP-generated products involved in this activity, we found that reactive oxygen species and the electric field induced by plasma were critical for enhanced and sustained migration persistence. Taken separately, these two stimuli were only partially active in inducing migration persistence at the dose that CAP generates. However, their combination was sufficient to recapitulate the full enhancement of migration persistence obtained with CAP exposure, indicating that these two stimuli act in synergy and that they likely represent the active components of CAP to activate migration of dermal fibroblasts during wound healing.
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