Evidence map›Paper›PMID 41310966›Full record

ArticleArthritis care & research2026

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis.

Patricia Vega-Fernandez, Pinar Ozge Avar-Aydin, Kelly Rogers, Daniel J Lovell, Jennifer Huggins, Alexei Grom, Hermine I Brunner, Grant S Schulert, Sheila T Angeles-Han, Mekibib Altaye and 3 more

Abstract readValidation Study
In one paragraph

Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patricia Vega-FernandezCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0002-4911-7256
Pinar Ozge Avar-AydinCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0002-7469-109X
Kelly RogersCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Daniel J LovellCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0003-1604-0130
Jennifer HugginsCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Alexei GromCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Hermine I BrunnerCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0001-9478-2987
Grant S SchulertCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0001-5923-7051
Sheila T Angeles-HanCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0002-9552-6464
Mekibib AltayeCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Amy CassedyCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Arthur B MeyersCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.ORCID https://orcid.org/0000-0002-5785-0861
Tracy V TingCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Center for Clinical and Translational Science and TrainingUM1TR005265 · NCATS · UNIVERSITY OF CINCINNATI · PI Jareen Meinzen-Derr, Jeffrey Robert Strawn · 2025 to 2026
$10.6M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)P30AR076316 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUNNER, HERMINE I · 2019 to 2023
$3.4M
Validation of a Novel Ultrasound Score to Improve the Assessment of Joint Inflammation in Children with Juvenile ArthritisK23AR081424 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Patricia Vega Fernandez · 2023 to 2026
$680k
National Center for Advancing Translational Sciences, NCATS 2KL2TR001426-05A1National Center for Advancing Translational Sciences, NCATS 2UL1TR001425-05A1National Institutes of Health, NIH K23AR081424ANational Institutes of Health, NIH P30AR076316NCATS NIH HHS KL2 TR001426NCATS NIH HHS UL1 TR001425NCATS NIH HHS UM1 TR005265NIAMS NIH HHS K23 AR081424NIAMS NIH HHS P30 AR076316
6 · The paper itself

Abstract

objectiveWe aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA).

methodsChildren with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the joint-specific PAUSS. A subset of children received contrast-enhanced magnetic resonance imaging (ceMRI) of the affected joint(s). The performance of the PAUSS as a measure of arthritis activity was compared to CE and ceMRI, using ceMRI as the reference standard.

resultsSeventy-five children contributed 44 elbows, 55 wrists, and 106 fingers for MSUS and 15 elbows, 16 wrists, and 40 fingers for ceMRI. B-mode PAUSS scores for the finger joints demonstrated moderate correlations with CE findings of arthritis, and the PAUSS-elbow noted a strong correlation. PAUSS scores for all joints showed a sensitivity of 75% to 94% in detecting synovitis when compared to ceMRI and good to excellent diagnostic accuracy for elbow and finger arthritis. The addition of MSUS to CE markedly improved the sensitivity of CE to 92% to 100%. The PAUSS and ceMRI scores for assessment of disease severity had strong correlation for each specific joint (r = 0.65-0.84, P ≤ 0.005).

conclusionThere is moderate to high sensitivity and diagnostic accuracy of the PAUSS in detecting synovitis in elbow, wrist, and finger joints, as well as a strong correlation of the PAUSS severity scores with the ceMRI severity scores, providing strong support that the PAUSS enhances the clinical assessment of disease activity in children with JIA.

Indexed as

Arthritis, JuvenileElbow JointFinger JointWrist JointAdolescentChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMalePredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexUltrasonography

Identifiers

PMID41310966
PMCPMC12860450

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.