Evidence map›Paper›PMID 41310957›Full record

ArticlePsychological medicine2025

Visuomotor dysconnectivity as a candidate mechanism of psychomotor agitation in major depression.

Victor Joseph Pokorny, Zachary Anderson, Allison M Letkiewicz, Dusan Hirjak, Sebastian Walther, Stewart Shankman, Vijay Mittal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Victor Joseph PokornyDepartment of Psychology, https://ror.org/000e0be47Northwestern University, Evanston, IL, USA.ORCID 0000-0002-1003-0196
Zachary AndersonDepartment of Psychology, https://ror.org/000e0be47Northwestern University, Evanston, IL, USA.ORCID 0000-0001-7253-8668
Allison M LetkiewiczStahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, https://ror.org/000e0be47Northwestern University, Evanston, IL, USA.
Dusan HirjakDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0003-1226-9800
Sebastian WaltherUniversity of Bern, Translational Research Center, https://ror.org/02k7v4d05University Hospital of Psychiatry and Psychotherapy, Bern, Switzerland.ORCID 0000-0003-4026-3561
Stewart ShankmanDepartment of Psychology, https://ror.org/000e0be47Northwestern University, Evanston, IL, USA.ORCID 0000-0002-8097-4483
Vijay MittalDepartment of Psychology, https://ror.org/000e0be47Northwestern University, Evanston, IL, USA.

Funding

An examination of psychomotor disturbance in current and remitted MDD: An RDoC StudyR01MH118741 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MITTAL, VIJAY A, SHANKMAN, STEWART AARON · 2019 to 2023
$3.4M
Motoric features of the voice as indicators of psychomotor agitation and retardation in current and remitted MDDR01MH134369 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MATTHEW A GOLDRICK, VIJAY A MITTAL · 2024 to 2026
$2.2M
Clarifying the Role of Psychomotor Retardation in Reward-Based Reinforcement Learning Deficits in MDD: A Computational and fMRI StudyK23MH129607 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Allison Letkiewicz · 2023 to 2026
$726k
Deutsche Forschungsgemeinschaft DFG HI1928/5-1, HI1928/6-1 and HI1928/14-1NIMH NIH HHS K23 MH129607NIMH NIH HHS K23MH129607NIMH NIH HHS R01 MH118741NIMH NIH HHS R01MH118741NIMH NIH HHS R01 MH134369NIMH NIH HHS R01MH134369
6 · The paper itself

Abstract

backgroundPsychomotor disturbance has long been observed in major depressive disorder (MDD) and is thought to be a key indicator of illness course. However, dominant methods of measuring psychomotor disturbance, via self-report and clinician ratings, often lack objectivity and may be less sensitive to subtle psychomotor disturbances. Furthermore, the neural mechanisms of psychomotor disturbance in MDD remain unclear.

methodsTo address these gaps, we measured psychomotor agitation via a force variability paradigm and collected resting fMRI in 47 individuals with current MDD (cMDD) and 93 individuals with remitted MDD (rMDD). We then characterized whether resting-state cortico-cortical and cortico-subcortical connectivity related to force variability and depressive symptoms.

resultsBehaviorally, individuals with cMDD exhibited greater force variability than rMDD individuals (

conclusionsOur findings represent a crucial step toward clarifying the pathophysiology of psychomotor agitation in MDD. Specifically, altered visuomotor functional connectivity emerged as a candidate neural mechanism, highlighting a promising direction for future research on dysfunctional visually guided movements in MDD.

Indexed as

Major Depressive DisorderPsychomotor AgitationPsychomotor PerformanceAdultConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedforce variabilitypsychomotor disturbanceresting state fMRI

Identifiers

PMID41310957
PMCPMC12927545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.