ArticleJournal of applied clinical medical physics2025
Commissioning a clinical linac for preclinical research of heterogeneous intratumor irradiation with end-to-end tests.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Commissioning a clinical linac for preclinical research of heterogeneous intratumor irradiation with end-to-end tests.Journal of applied clinical medical physics · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundAlthough it is not clear how the heterogeneous intratumor irradiation pattern affects the biological effect, investigations of the biological effect dependence on the dose and size of the peak region are essential in the current preclinical research. PURPOSE: This work develops and validates a cone-equipped clinical linac platform for heterogeneous intratumor irradiation (HII) of small animals, making translationally relevant preclinical radiobiology studies accessible to more clinical centers.
methodsOutput ratios (ORs) for cones (from 4 mm to 17.5 mm diameters) were measured using Gafchromic EBT3 films on a Varian TrueBeam linac (6 MV FFF beam). Tissue maximum ratios (TMR) and off-axis ratios (OAR) were incorporated into the Eclipse treatment planning system (TPS) to configure the beam model. End-to-end test was performed using both a mouse phantom and tumor-bearing mice, with dose distributions verified via film dosimetry and γ analysis (3%/3 mm and 3%/2 mm criteria).
resultsThe system achieved millimeter-scale precision, with γ pass rates ≥ 99% (3%/2 mm). Dose distributions confirmed the feasibility of delivering heterogeneous doses (e.g., 14 Gy via 4 mm cone + 2 Gy via 15 mm cone) while sparing normal tissues.
conclusionThis study established a robust preclinical HII platform using clinical linac infrastructure, enabling precise dose delivery for investigating dose-response relationships and supporting future translational research.
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