ArticleNutrition & metabolism2025
High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06384365 (Interaktion Von Ausgewählten Inflammationsparametern, Geschmackswahrnehmung Und Geschmackspräferenzen in Abhängigkeit Von Physischer Aktivität Und Körperzusammensetzung), which is not on this map. Cited by 1 paper.
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Interaktion Von Ausgewählten Inflammationsparametern, Geschmackswahrnehmung Und Geschmackspräferenzen in Abhängigkeit Von Physischer Aktivität Und Körperzusammensetzung
Who cites it
1 citing paper in PubMed.
- Taste receptor downregulation in diet-induced obesity reveals circumvallate papillae-specific taste-inflammatory networks.Frontiers in nutrition · 2026Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDisease-related inflammation affects chemosensory signaling, but knowledge on the impact of exercise-induced low-grade inflammation on taste function remains scarce. Here we hypothesized that intense habitual physical activity modifies sweet taste perception via increased cytokine release.
methodsIn an observational human study we compared participants (m/f) engaging in high (n = 34) and low (n = 31) levels of habitual physical activity. Salivary IL-6 and urinary 8-iso-prostaglandin F2α levels, body composition, sucrose recognition threshold, preference and consumption of sweet foods, size and area of fungiform papillae as well as selected hormones regulating food intake were recorded. Statistical analysis was conducted using Principal Component Analysis (PCA) followed by Student’s t-tests and multiple regression models.
resultsThe PCA summarized the main outcome variables to two principal components (PC). PC1 was primarily influenced by body composition and fungiform papillae markers, while sucrose recognition thresholds, sweet food consumption, and IL-6 levels strongly contributed to PC2. Compared to the low activity group, the high activity group showed on average an increased sucrose recognition threshold (+ 35.8 ± 12.8%), increased IL-6 concentrations (+ 25.6 ± 10.9%), higher consumptions of sweet foods (+ 18.8 ± 4.9%) and decreased number (24.8 ± 4.9%) and area (-29.8 ± 6.4%) of fungiform papillae.
conclusionsThe association between modified sweet taste function markers and increased IL-6 levels suggests that inflammatory processes may contribute to exercise-related changes in chemosensory perception.
trial registrationThe study was approved by the Ethics Committee of the University of Vienna (approval number 01125) and registered at ClinicalTrial.gov (NCT06384365).
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