ArticleJournal of nanobiotechnology2025
Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions.Gels (Basel, Switzerland) · 2026Review
- Modern Drug Delivery Platforms Based on Photocrosslinkable Hydrogels (PCHs) in Dentistry: From Material Characteristics to Clinical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Dimensionally Engineered Nanotherapeutics for Pulpitis and Periodontitis: From Structural Design to Artificial Intelligence-Enabled Precision Therapy.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently used in clinical practice still have critical limitations, including low penetration efficiency of antimicrobial agents, poor anti-inflammatory effects, and a lack of effective strategies to promote functional dentin regeneration. These factors restrict the therapeutic efficacy of pulp vitality preservation treatments. In this study, by constructing a composite of Metal-Organic Framework (MOF@Cr-Al) and methacrylated gelatin (GelMA), we have developed a photo-curable multifunctional hydrogel (GelMA-MOF@Cr-Al) with potential for clinical translation. The MOF@Cr-Al exhibits strong reactive oxygen species scavenging ability and broad-spectrum antibacterial effects. The photo-responsive rapid cross-linking properties of the GelMA hydrogel provide adaptability for clinical operations, and its three-dimensional network structure can sustainably regulate the release of metal ions. In the pulpitis animal experiment, GelMA-MOF@Cr-Al significantly alleviated inflammation and effectively promoted the formation of orderly reparative dentin. Overall, this multifunctional hydrogel provides an extremely innovative solution for pulp vitality preservation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.