Evidence map›Paper›PMID 41310620›Full record

ReviewJournal of nanobiotechnology2025

mRNA vaccines: immunogenicity and quality characteristics.

Yaru Quan, Huijie Yang, Wei Li, Linxian Li

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yaru QuanDivision of Respiratory Virus Vaccines, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing, 102629, China.
Huijie YangWalvax Biotechnology Co., Ltd, 395 Kexin Road, High-Tech Zone, Kunming City, Yunnan Province, China.
Wei LiWalvax Biotechnology Co., Ltd, 395 Kexin Road, High-Tech Zone, Kunming City, Yunnan Province, China. yxwslw@walvax.com.
Linxian LiDepartment of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong. lxli@surgery.cuhk.edu.hk.

Funding

NMPA Key Laboratory for Quality Research and Evaluation of Biological Products NMPA Key Laboratory for Quality Research and Evaluation of Biological Products
6 · The paper itself

Abstract

mRNA vaccine technology platform has evolved rapidly in recent years, which has emerged as an important direction in vaccine development. Establishing a quality control platform based on its Critical Quality Attributes (CQAs) is fundamental to ensuring vaccine efficacy and safety. This paper systematically explores the key quality attributes of mRNA vaccines and their impact on vaccine immunogenicity. Additionally, it introduces the technical principles, development status, key quality control items and their significance, as well as immunogenicity indicators of mRNA vaccines, and discusses the critical importance of studying the correlation between CQAs and immunogenicity.

Indexed as

Immunogenicity, VaccinemRNA VaccinesRNA, MessengerVaccinesVaccines, SyntheticAnimalsHumansQuality ControlVaccine DevelopmentmRNA VaccinesRNA, MessengerVaccinesVaccines, SyntheticCritical quality attributesmRNA vaccineSafetyVaccine efficacyVaccine immunogenicity

Identifiers

PMID41310620
PMCPMC12765321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.