Evidence map›Paper›PMID 41310604›Full record

ArticleBMC oral health2025

Cannabinoid receptor 2 affect the inflammatory response in periodontitis by regulating macrophage M1/M2 polarization.

Shu-Yue Yuan, Fei Zhao, Ran Tao, Bing Liu, Chun-Yan Liu

Abstract read
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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shu-Yue YuanDepartment of Endodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China.
Fei ZhaoDepartment of Periodontology I, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China.
Ran TaoDepartment of Education, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China.
Bing LiuDepartment of Periodontology I, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China. liubing@hebmu.edu.cn.
Chun-Yan LiuDepartment of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China. chunyanliu@hebmu.edu.cn.

Funding

the Research Projects of Hebei Province Government Funding the Training of Excellent Clinical Medical Talents and Fundamental Research 361029(MXZB00271)
6 · The paper itself

Abstract

objectiveThis study investigated the effect of cannabinoid receptor 2 (CB2R) on macrophage polarization and inflammatory severity in periodontitis, elucidating CB2R's potential role in the disease.

methodsChronic periodontitis was induced by ligating maxillary second molars with orthodontic filaments in wild-type (WT) and CB2R knockout (CB2R

results1. Micro-CT revealed significantly greater alveolar bone resorption in both CB2R

conclusionsCB2R deficiency exacerbates alveolar bone resorption and inflammatory severity in periodontitis, potentially by dysregulating macrophage M1/M2 polarization and inflammatory cytokine expression.

Indexed as

Chronic PeriodontitisMacrophagesPeriodontitisReceptor, Cannabinoid, CB2Alveolar Bone LossAnimalsCytokinesDisease Models, AnimalInflammationMaleMiceMice, Inbred C57BLMice, KnockoutX-Ray MicrotomographyCytokinesReceptor, Cannabinoid, CB2Cannabinoid receptor 2M1/M2 polarizationMacrophagesPeriodontitis

Identifiers

PMID41310604
PMCPMC12752204

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.