ArticleBMC medical genomics2025
PICALM polymorphisms are associated with susceptibility to parkinson's disease in the Northern Chinese Han population: a case-control study.
Article in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundParkinson's disease (PD) is the second most common neurodegenerative disease. The phosphatidylinositol binding clathrin assembly protein (PICALM) gene has been implicated in neurodegenerative diseases. However, molecular genetic investigations into the role of the PICALM gene in PD within Chinese population are still lacking.
aimWe aim to determine whether two single nucleotide polymorphisms rs642949 and rs510566, in the PICALM gene are associated with the risk and clinical features of PD.
methodsA total of 400 individuals with PD and 477 healthy controls were recruited. Genotyping of the PICALM gene loci (rs510566 and rs642949) was performed using TaqMan-based polymerase chain reaction-restriction fragment length polymorphism using DNA samples.
resultsFor rs642949, the GA genotype conferred a significantly reduced risk of PD under additive model (P
conclusionsThe rs642949 might be associated with susceptibility to PD. In contrast, no such association was found for the rs510566. Further fundamental research is warranted to investigate the PICALM gene in PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.