Evidence map›Paper›PMID 41310588›Full record

ArticleHealth and quality of life outcomes2025

Association between social support and quality of life in community-dwelling schizophrenics: the mediating roles of anxiety and depression symptoms.

Yue Chen, Xuanyi Hu, Chaoxinyu Xiong, Yi Guo, Luyi Wei, Xiaoyan Wan, Qin Yang, Changjiu He, Yuanyuan Liu, Xiang Liu

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In one paragraph

Article in Health and quality of life outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Yue Chen *Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China.
Xuanyi Hu *The Fourth People's Hospital of Chengdu, Chengdu, Sichuan, China.
Chaoxinyu XiongDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China.
Yi GuoDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China.
Luyi WeiDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China.
Xiaoyan WanHealth Management Training Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Qin YangThe Fourth People's Hospital of Chengdu, Chengdu, Sichuan, China.
Changjiu HeThe Fourth People's Hospital of Chengdu, Chengdu, Sichuan, China.
Yuanyuan LiuDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China. y_multi@126.com.
Xiang LiuDepartment of Health Behavior and Social Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, China. new9812@126.com.

Funding

National Natural Science Foundation of China 81903414Science and Technology Program of Sichuan Province 2025ZNSFSC0782
6 · The paper itself

Abstract

backgroundThe quality of life of schizophrenics is an important public health issue, but studies exploring the mechanisms that contribute to the quality of life are still lacking. We aimed to investigate the relevance of social support, anxiety and depression symptoms on the quality of life in community-dwelling schizophrenics, particularly the mediating roles of these symptoms between social support and quality of life.

methodsData were collected from a cohort study of community-dwelling schizophrenics in west China. The relationship between main variables was discussed through correlation analysis. Causal mediation analysis was used to explore the direct effect of social support on patients' quality of life and the indirect effect through anxiety and depression symptoms.

resultsOf 915 included participants, the mean age was 50.85 (SD = 12.48) years, and 437 (47.76%) were males. Social support was negatively correlated with anxiety and depression symptoms and positively correlated with quality of life. Anxiety and depression symptoms were both negatively correlated with quality of life. The results of parallel multiple mediation analysis showed that anxiety and depression symptoms jointly mediated this association. The total natural indirect effect of social support on physical health was 0.060 (95%CI: 0.036, 0.089) and on mental health was 0.084 (95%CI: 0.046, 0.127). But no significant direct effect was found in the multiple mediation analysis of social support on mental health.

conclusionsSocial support can affect quality of life either directly or indirectly through anxiety and depression symptoms in community-dwelling schizophrenics. It may provide references for subsequent studies on related mechanisms of action.

Indexed as

AnxietyDepressionQuality of LifeSocial SupportAdultAgedChinaCohort StudiesFemaleHumansIndependent LivingMaleMiddle AgedAnxietyDepressionMediation analysisQuality of lifeSchizophreniaSocial support

Identifiers

PMID41310588
PMCPMC12751270

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