ReviewBMC neurology2025
Imaging findings of Balamuthia mandrillaris amoebic encephalitis in 2 cases with different prognosis and literature review.
Review in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The first reported case ofFrontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBalamuthia mandrillaris amoebic encephalitis is a rare granulomatous amoebic encephalitis caused by infection with Balamuthia mandrillaris with a fatality rate over 90%. This study characterizes the imaging manifestations of Balamuthia mandrillaris amoebic encephalitis, yields critical new insights into the intracranial dissemination mechanisms of Balamuthia mandrillaris. CASE PRESENTATION: We present two cases of Balamuthia mandrillaris amoebic encephalitis confirmed through Next-generation sequencing of cerebrospinal fluid and brain biopsy in our hospital, with different imaging manifestations and prognosis (One death). Meanwhile, we reviewed 16 surviving cases of Balamuthia mandrillaris amoebic encephalitis reported in literatures up to now.
conclusionBased on 17 surviving patients imaging findings with clinical data and one death case we reported, we proposed that the key imaging features related to the prognosis of Balamuthia mandrillaris amebic encephalitis are hemorrhage within the lesion and centripetal spread through cortical and subcortical brain parenchyma into cerebrospinal fluid circulation along the meninges and ependyma. Starting ventriculoperitoneal shunt surgery as early as possible before the ventricular system is invaded may provide the patient with a chance of survival.
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