ArticleBMC anesthesiology2025
Association between gut microbiota dysbiosis and perioperative neurocognitive disorder and postoperative complications after valve replacement surgery: a prospective cohort study.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the relationship between gut microbiota disorder and perioperative neurocognitive disorder (PND) and postoperative complications after valve replacement.
methodsThis prospective cohort study involved the patients above 50 years old undergoing elective heart valve replacement surgery. Postoperatively, the cognitive status on the first day without sedation after extubation was assessed. The microbial composition of the feces discharged for the first time after surgery was analyzed, and clinical symptoms of significant disruption in gastrointestinal microbiome within 7 days postoperatively were recorded. Patients with positive microbial results or clinical symptoms were categorized into the intestinal microbial disruption group, while the rest were the normal group. Subsequent analyses were conducted after propensity score matching for age, education duration, and gender between different microbial groups.
resultsThe final inclusion comprised 194 patients, In the PND group, patients had a significantly higher average age(P=0.002) comprising with normal group. Patients in the gut microbiota disturbance group had a higher average age compared to the normal group (P=0.005), with a significantly increased likelihood of developing PND (P=0.001) and other postoperative complications(P=0.008). After propensity score matching, establishing a matched queue consisting of 74 patient pairs, the incidence of PND in the flora disturbance group was 28.4% (21/74), higher than the normal group's 13.5% (10/74) (P=0.026).
conclusionsThe incidence of cognitive dysfunction and gut microbiota disorder after cardiac surgery is high, especially in elderly patients. Gastrointestinal microbiome dysbiosis is significantly associated with PND and other postoperative complications. Gastrointestinal microbiome dysbiosis is a risk factor for both PND and other postoperative complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.