SynthesisBMC geriatrics2025
Frailty as a predictor of postoperative outcomes in older gastroesophageal cancer patients: a systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Review
- A Commentary on "Impact of preoperative frailty on venous thromboembolism risk following total hip and knee arthroplasty: a meta-analysis".International journal of surgery (London, England) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty disproportionately impacts older patients with cancer, rendering them at increased risk for poor surgical outcomes. However, the impact of frailty on postoperative outcomes in the population with older gastroesophageal cancer remains unknown.
methodsSystematic review and meta-analysis of studies reporting frailty in older gastroesophageal cancer surgery patients searching Embase, PubMed, Scopus, and Web of Science. The pooled prevalence and odds ratio (OR) with 95% confidence intervals (CI) for mortality and complications estimates were analyzed. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). Data were pooled using random-effects models.
resultsA total of 16 studies involving 6143 older patients with gastroesophageal cancer were included. The prevalence of frailty in older gastroesophageal cancer patients was 28% (95% CI = 20-36; p < 0.0001). Frailty was associated with an increased odds ratio for mortality (OR = 2.66; 95% CI = 1.49-4.78; p = 0.0010) and major complication (OR = 2.65; 95% CI = 2.17-3.25; p < 0.0001) compared with non-frail older gastric cancer patients, adjusted for potential confounders.
conclusionFrailty is frequent in older gastroesophageal cancer patients and may predict adverse outcomes in older gastroesophageal cancer with surgery. The findings underline the significance of frailty evaluation among this population.
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