ArticleBMC infectious diseases2025
Clinical characteristics and management of Listeria monocytogenes meningitis in children beyond the neonatal stage: a 10 years retrospective study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Listerial rhombencephalitis diagnosed by repeat blood culture despite negative CSF PCR: a case report.ASM case reports · 2026Article
- Listeria monocytogenes meningitis beyond the neonatal period: a multicenter case series of previously unpublished pediatric cases from Türkiye.European journal of pediatrics · 2026Observational
- A Multiplex One-Tube Nested Real-Time PCR Assay for the Point-of-Care Testing of Infectious Meningitis.Pathogens (Basel, Switzerland) · 2026Article
- Inappropriate Antimicrobial Regimen Leading to RecurrentInfection and drug resistance · 2026Article
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9 authors.
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Abstract
introductionThe data of Listeria monocytogenes (LM) meningitis in children beyond the neonatal stage has been limited. We aimed to summarize the clinical characteristics, management, and risk factors of neurological complications in LM meningitis children beyond the neonatal stage.
methodsWe retrospectively reviewed LM meningitis cases from January 2013 to December 2022 at Beijing Children’s Hospital. Clinical characteristics, pathogen detection results and management were analyzed.
resultsThere were 41 LM meningitis patients at our center, with a median age of 2.3 years (ranging from 6 months to 9 years). Most patients (97.6%) were immunocompetent. Fourteen patients (34.1%) had a history of suspected food contamination. The most common symptom was fever (100%), and 29.2% of patients presented with diarrhea in the early stages of the disease. About 61% of patients showed monocyte predominance in their cerebrospinal fluid (CSF). Thirteen patients (31.7%) experienced neurological complications. Multivariate analysis indicated that a diagnosis delay of more than one week and a CRP level of 50 mg/L or higher were significant risk factors for these neurological complications (p < 0.05). CSF culture rates were much higher before hospital admission (85.7%) compared to after (31.7%, p < 0.05). Metagenomic next-generation sequencing (mNGS) identified pathogens in 3 culture-negative cases. In total, 97.5% of patients received meropenem, either alone or with other antibiotics, and all children recorded a Glasgow Outcome Scale (GOS) score of 5.
conclusionLM meningitis can affect immunocompetent children. Strengthening food hygiene and safety education is crucial to prevent LM infection. Penicillin or ampicillin are the preferred treatments, while meropenem may be considered as an alternative treatment.
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