ArticleBMC genomics2025
Genomic characterization of clinical Borrelia burgdorferi sensu lato isolates in the Netherlands over a thirty-year period.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
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14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLyme borreliosis (LB), the most common vector-borne disease in the Northern Hemisphere, is caused by a multitude of pathogenic Borrelia burgdorferi sensu lato (sl) species endemic to northern, western, and central regions of Europe. We utilized whole genome sequencing (WGS) to characterize the genetic diversity of 130 clinical B. burgdorferi sl isolates collected from LB cases in the Netherlands between 1988 and 2023, the majority of which were B. afzelii.
resultsWGS analysis revealed significant diversity, including 29 different multi-locus sequence types (MLSTs) across four genospecies. Plasmids from B. garinii and B. bavariensis were found to exhibit greater sequence diversity than those from B. burgdorferi sensu stricto and B. afzelii. We further characterized the Borrelia membrane protein antigens OspA, OspC and DbpA for sequence diversity and correlation with LB disease state.
conclusionsThis large-scale genomic analysis of clinical Dutch B. burgdorferi sl isolates furthers our understanding of LB and may indicate potential coverage for LB vaccine candidates in clinical development.
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