Evidence map›Paper›PMID 41310380›Full record

ArticleScientific reports2025

Percutaneous extraction using sponge spicules for disease diagnosis and therapeutic drug monitoring.

Shimeng Li, Shiyan Zhang, Mengnan Jia, Siqing Chen, Ran Zhang, Yuhan Liu, Guoliang Yan, Ming Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shimeng LiDepartment of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China.
Shiyan ZhangBasic Medical Department of School of Medicine, Xiamen University, Xiamen, 361102, China.
Mengnan JiaDepartment of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China.
Siqing ChenBasic Medical Department of School of Medicine, Xiamen University, Xiamen, 361102, China.
Ran ZhangBasic Medical Department of School of Medicine, Xiamen University, Xiamen, 361102, China.
Yuhan LiuThe College of Materials, Xiamen University, Xiamen, 361102, China.
Guoliang YanBasic Medical Department of School of Medicine, Xiamen University, Xiamen, 361102, China. zhuanyiyan@126.com.
Ming ChenDepartment of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China. ming.chen@xmu.edu.cn.

Funding

College Students' Innovative Entrepreneurial Training Plan Program S202410384619Fujian Ocean and Fisheries Department FJHJFL-2023-32Natural Science Foundation of Fujian Province of China 2022J01025Scientific Research Foundation of State Key Laboratory of Vaccines for Infectious Diseases，Xiang An Biomedicine Laboratory 2023XAKJ0101003Xiamen Marine and Fisheries Development Fund 21CZP002HJ05
6 · The paper itself

Abstract

Diagnostic and therapeutic drug monitoring are necessary means of precision medicine. Our previous study demonstrated that the sponge Haliclona sp. spicules (SHS) can be employed as a new class of microneedles, capable of forming a substantial number of microchannels within the skin. In this study, dermal interstitial fluid (ISF) was obtained via percutaneous extraction using sponge Haliclona sp. spicules (SHS) to explore the correlation between the concentration of target compounds in the extract and their content in the skin or blood. Methodologically, we compared SHS with dermaroller, ultrasound, and reverse iontophoresis for interstitial fluid (ISF) extraction efficacy in vitro, while optimizing extraction parameters (dosage of SHS, extraction solvent, extraction time) via orthogonal experimental design. Target compounds spanning diverse physicochemical properties (fluorescein sodium, rhodamine B, salicylic acid, FD 1 k, urea, glucose) were evaluated. We also detected the concentration of target compounds and their levels in the blood in vivo. Key results showed that robust linear correlations were observed between the detected concentration of target compounds through SHS and their levels in various skin layers, as well as in the blood. Additionally, we developed a mathematical model predicting extraction efficiency log k

Indexed as

Drug MonitoringPoriferaSkinAnimalsExtracellular FluidHumansIontophoresisDisease diagnosisPercutaneous extractionSponge spiculesTherapeutic drug monitoring

Identifiers

PMID41310380
PMCPMC12749520

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