Evidence map›Paper›PMID 41310351›Full record

ArticleNature communications2025

Dysregulation of homeostatic cytokine receptors drives prolonged T cell activation following acute SARS-CoV-2 infection in humans.

Laura Ceglarek, Patrick Taeschler, Alp Inci, Yves Zurbuchen, Sarah Adamo, Carlo Cervia-Hasler, Miro E Raeber, Onur Boyman

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura CeglarekCenter for Human Immunology, University of Zurich, Zurich, Switzerland.ORCID 0009-0005-7117-0335
Patrick TaeschlerDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-0522-7629
Alp InciCenter for Human Immunology, University of Zurich, Zurich, Switzerland.ORCID 0009-0009-7671-7570
Yves ZurbuchenCenter for Human Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5387-9950
Sarah AdamoDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Carlo Cervia-HaslerDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Miro E RaeberCenter for Human Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2609-0246
Onur BoymanCenter for Human Immunology, University of Zurich, Zurich, Switzerland. onur.boyman@uzh.ch.ORCID 0000-0001-8279-5545

Funding

Schweizerische Akademie der Medizinischen Wissenschaften (Swiss Academy of Medical Sciences) 323530-177975Schweizerische Akademie der Medizinischen Wissenschaften (Swiss Academy of Medical Sciences) 323530-191220Schweizerische Akademie der Medizinischen Wissenschaften (Swiss Academy of Medical Sciences) 323530-191230Schweizerische Akademie der Medizinischen Wissenschaften (Swiss Academy of Medical Sciences) Talents in Clinical Research Project Grant (YTCR 08/20)Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030-172978Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) NRP78 Implementation Programme
6 · The paper itself

Abstract

Acute viral infections are usually cleared by an efficient anti-pathogen immune response, following which immune homeostasis is restored. Occasionally, such pathogen-induced immune response fails to abate despite clinical recovery, but how this occurs in humans has not been thoroughly investigated. Here, we perform a detailed analysis of T cell homeostasis following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, which reveals persistent activation and dyshomeostasis of CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19Lymphocyte ActivationReceptors, CytokineSARS-CoV-2AdultCytokinesFemaleHomeostasisHumansInterleukin-15Interleukin-2Interleukin-7MaleMiddle AgedCytokinesIL15 protein, humanIL7 protein, humanInterleukin-15Interleukin-2Interleukin-7Receptors, CytokineReceptors, Interleukin-2Receptors, Interleukin-7

Identifiers

PMID41310351
PMCPMC12748759

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.