Evidence map›Paper›PMID 41310324›Full record

ArticleScientific reports2025

Multi-omics and experimental validation identify methylation-related genes and METTL16 as key regulators in diabetic foot ulcer pathogenesis.

Yilan Tong, Sicheng Li, Lei Shen, Lingling Yan, Zhanyong Zhu, Qingquan Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yilan Tong *Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Sicheng Li *Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Lei Shen *Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
Lingling YanDepartment of Plastic and Cosmetic Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China. yanll197803@126.com.
Zhanyong ZhuDepartment of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. zyzhu@whu.edu.cn.
Qingquan HuaDepartment of Otorhinolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. rm001637@whu.edu.cn.

Funding

Enshi Innovation and Development Joint Fund JCZRLH202500476Industry-University-Research Innovation Fund for Chinese Universities 2021ITA03006Online Education and Teaching Research Project for Graduate Students in Chinese Medicine B YXC2024-02-03 10
6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are a severe complication of diabetes, characterized by impaired wound healing, chronic inflammation, and tissue degradation. N

Indexed as

Diabetic FootDNA MethylationMethyltransferasesAdenosineBiomarkersFibroblastsGene Expression ProfilingGene Expression RegulationHumansMethylationMultiomicsOxidative StressWound HealingAdenosineBiomarkersMethyltransferasesN-methyladenosineDiabetic foot ulcerImmune regulationMethylation-related genesMETTL16Single-cell RNA sequencingWound healing

Identifiers

PMID41310324
PMCPMC12661024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.